Which Hypertensive Drugs Cause Gynecomastia?

Angiotensin converting enzyme inhibitors, spironolactone, digoxin, amiodarone, verapamil, diltiazem and nifedipine are all medications commonly used in cardiology practice and have been linked to gynecomastia.

Which Hypertensive Drugs Cause Gynecomastia?

Angiotensin converting enzyme inhibitors, spironolactone, digoxin, amiodarone, verapamil, diltiazem and nifedipine are all medications commonly used in cardiology practice and have been linked to gynecomastia. Calcium channel blockers such as verapamil, nifedipine and diltiazem, ACE inhibitors like captopril and enalapril, digoxin, cytotoxic agents and marijuana have all been associated with this condition. Gynecomastia can be caused by a variety of drugs, which can be divided into categories based on their likelihood of causing the condition. Hyperthyroidism, chronic renal failure, adrenal hyperplasia or tumors, amphetamine, cyclosporine and anabolic steroids are all secondary causes of hypertension that can lead to gynecomastia.

Reserpine, methyldopa and spironolactone are older drugs that have been linked to gynecomastia. However, calcium antagonists, angiotensin converting enzyme inhibitors and alpha-blockers may also be associated with this condition. If gynecomastia is caused by an underlying treatable cause such as a drug, it usually responds to treatment or the elimination of the root cause.

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